skip to Main Content

The effect of daily UVA phototherapy for 2 weeks on clinical and 24-h blood pressure in people with mild hypertension

  • Murray CJ, Ezzati M, Flaxman AD, Lim S, Lozano R, Michaud C, et al. GBD 2010: design, definitions and metrics. Lancet. 2012;380:2063–6.

    Article

    Google Scholar

  • Alfredsson L, Armstrong BK, Butterfield DA, Chowdhury R, ​​de Gruijl FR, Feelisch M, et al. Insufficient sun exposure has become a real public health problem. Int J Environ Res Public Health 2020;17:5014.

    CASE
    Article

    Google Scholar

  • Weller RB, Feelisch M, Kotanko P. Correspondence on “Seasonal variation in blood pressure: evidence, consensus and recommendations for clinical practice.” ESH Working Group Consensus Statement on Blood Pressure Monitoring and Cardiovascular Variability”. J Hypertens. 2020;38:2077–9.

    CASE
    Article

    Google Scholar

  • Stewart S, Keates AK, Redfern A, McMurray JJV. Seasonal variations in cardiovascular disease. Nat Rev Cardiol. 2017;14:654–64.

    Article

    Google Scholar

  • Weller RB, Wang Y, He J, Maddux FW, Usvyat L, Zhang H, et al. Does incident solar ultraviolet radiation lower blood pressure? J Am Heart Assoc. 2020;9:e013837.

    CASE
    Article

    Google Scholar

  • Bustamante M, Hernandez-Ferrer C, Sarria Y, Harrison GI, Nonell L, Kang W, et al. The acute effects of ultraviolet radiation on the blood transcriptome are independent of plasma 25OHD3. Approx Res. 2017;159:239–48.

    CASE
    Article

    Google Scholar

  • Liu D, Fernandez BO, Hamilton A, Lang NN, Gallagher JMC, Newby DE, et al. UVA irradiation of human skin vasodilates the arterial vasculature and lowers blood pressure independently of nitric oxide synthase. J Invest Dermatol. 2014;134:1839–46.

    CASE
    Article

    Google Scholar

  • Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Hypertension Society. J Hypertens. 2018;36:1953–2041.

    CASE
    Article

    Google Scholar

  • Weatherall IL, Combes BD. Measurements of skin color in terms of CIELAB color space values. J Investigative Dermatol. 1992;99:468–73.

    CASE
    Article

    Google Scholar

  • Hata T, Ogihara T, Maruyama A, Mikami H, Nakamaru M, Naka T, et al. Seasonal variation of blood pressure in patients with essential hypertension. Clin Exp Hypertension Part A, Theory Pract. 1982;4:341–54.

    CASE
    Article

    Google Scholar

  • Youn JC, Rim SJ, Park S, Ko YG, Kang SM, Choi D, et al. Arterial stiffness is related to increased seasonal variation in blood pressure in hypertensive patients. Blood press. 2007;16:375–80.

    Article

    Google Scholar

  • Ignarro L. Nitric Oxide. A new signal transduction mechanism for transcellular communication. Hypertension. 1990;16:477–83.

    CASE
    Article

    Google Scholar

  • Mowbray M, McLintock S, Weerakoon R, Lomatschinsky N, Jones S, Rossi AG, et al. Enzyme-independent NO stocks in human skin: quantification and influence of UV radiation. J Invest Dermatol. 2009;129:834–42.

    CASE
    Article

    Google Scholar

  • Lundberg JO, Weitzberg E, Gladwin MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapy. Nat Rev Drug Disco. 2008;7:156–67.

    CASE
    Article

    Google Scholar

  • Larsen FJ, Ekblom B, Sahlin K, Lundberg JO, Weitzberg E. Effects of dietary nitrate on blood pressure in healthy volunteers. N. Engl J Med. 2006;355:2792–3.

    CASE
    Article

    Google Scholar

  • Dejam A, Kleinbongard P, Rassaf T, Hamada S, Gharini P, Rodriguez J, et al. Thiols increase NO formation from nitrate photolysis. Free radical Biol Med. 2003;35:1551–9.

    CASE
    Article

    Google Scholar

  • Furchgott RF, Ehrreich SJ, Greenblatt E. Photoactivated relaxation of rabbit aortic smooth muscle. J Gen Physiol. 1961;44:499–519.

    CASE
    Article

    Google Scholar

  • Rodriguez J, Maloney RE, Rassaf T, Bryan NS, Feelisch M. Chemical nature of nitric oxide storage forms in rat vascular tissue. Proc Natl Acad Sci USA. 2003;100:336–41.

    CASE
    Article

    Google Scholar

  • Oplander C, Volkmar CM, Paunel-Gorgulu A, van Faassen EE, Heiss C, Kelm M, et al. Whole-body UVA irradiation lowers systemic blood pressure by releasing nitric oxide from intracutaneous photolabile nitric oxide derivatives. Circ Res. 2009;105:1031–40.

    Article

    Google Scholar

  • Pelegrino MT, Paganotti A, Seabra AB, Weller RB. Photochemistry of nitric oxide and S-nitrosothiols in human skin. Histochem Cell Biol. 2020;153:431–41.

    CASE
    Article

    Google Scholar

  • Bae JM, Kim YS, Choo EH, Kim MY, Lee JY, Kim HO, et al. Cardiovascular and cerebrovascular events are diminished after long-term narrowband ultraviolet B phototherapy in patients with vitiligo: a propensity score matching analysis. J Eur Acad Dermatol Venereol. 2021;35:222–9.

    CASE
    Article

    Google Scholar

  • Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, et al. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Metab cell. 2011;13:149–59.

    CASE
    Article

    Google Scholar

  • Van De Walle GP, Vukovich MD. The effect of nitrate supplementation on exercise tolerance and performance: a systematic review and meta-analysis. J Resistance Conditioning Res. 2018;32:1796–808.

    Article

    Google Scholar

  • Muggeridge DJ, Sculthorpe N, Grace FM, Willis G, Thornhill L, Weller RB, et al. Acute whole-body UVA irradiation combined with nitrate ingestion improves time trial performance in trained cyclists. Nitric oxide. 2015;48:3–9.

    CASE
    Article

    Google Scholar

  • Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, Patel K, et al. Systematic review: Vitamin D and cardiometabolic outcomes. Ann Intern Med. 2010;152:307–14.

    Article

    Google Scholar

  • Chowdhury R, ​​Stevens S, Ward H, Chowdhury S, Sajjad A, Franco OH. Circulating vitamin D, calcium and risk of cerebrovascular disease: systematic review and meta-analysis. Eur J Epidemiol. 2012;27:581–91.

    CASE
    Article

    Google Scholar

  • Scragg RKR. Overview of the results of the Vitamin D Assessment Study (ViDA). J Endocrinological Investig. 2019;42:1391–9.

    CASE
    Article

    Google Scholar

  • Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, et al. Vitamin D supplements and the prevention of cancer and cardiovascular disease. NEJM. 2018;380:33–44.

    Article

    Google Scholar

  • Zhang D, Cheng C, Wang Y, Sun H, Yu S, Xue Y, et al. Effect of vitamin D on blood pressure and hypertension in the general population: an updated meta-analysis of cohort studies and randomized controlled trials. Prev Chronicle Dis. 2020;17:E03.

    Article

    Google Scholar

  • Afzal S, Brondum-Jacobsen P, Bojesen SE, Nordestgaard BG. Genetically low vitamin D levels and increased mortality: Mendelian randomization analysis in three large cohorts. BMJ. 2014;349:g6330.

    Article

    Google Scholar

  • Vimaleswaran KS, Cavadino A, Berry DJ, Jorde R, Dieffenbach AK, Lu C, et al. Association of vitamin D status with blood pressure and risk of hypertension: a Mendelian randomization study. Diabetes Endocrinol lancet. 2014;2:719–29.

    CASE
    Article

    Google Scholar

  • Sofianopoulou E, Kaptoge SK, Afzal S, Jiang T, Gill D, Gundersen TE, et al. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomization analyses. Lancet Diabetes Endocrinol. 2021;9:837–46.

    Article

    Google Scholar

  • Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2014;2:76–89.

    CASE
    Article

    Google Scholar

  • Rahimi K, Bidel Z, Nazarzadeh M, Copland E, Canoy D, Ramakrishnan R, et al. Pharmacological blood pressure lowering for the primary and secondary prevention of cardiovascular disease at different blood pressure levels: a meta-analysis of individual participant-level data. Lancet. 2021;397:1625–36.

    Article

    Google Scholar

  • Armstrong BK, Customer AE. Sun exposure and skin cancer, and the conundrum of cutaneous melanoma: a perspective on Fears et al. Mathematical models of the effects of age and ultraviolet on the incidence of skin cancer among whites in the United States. American Journal of Epidemiology 1977; 105: 420–427. Cancer epidemiology. 2017;48:147–56.

    Article

    Google Scholar

  • Back To Top